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Beclometasone dipropionate

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Purity:99.44%

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Beclometasone dipropionate

Catalog No. T1127Cas No. 5534-09-8

Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.

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Pack Size	Price	Availability
100 mg	$31	In Stock
200 mg	$46	In Stock
250 mg	$50	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.
In vitro	Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.
Alias	Beclovent, Beclomethasone dipropionate, Beconase, Vancenase

Chemical Properties

Molecular Weight	521.04
Formula	C28H37ClO7
Cas No.	5534-09-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (105.56 mM)

Ethanol: 18 mg/mL (34.55 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9192 mL	9.5962 mL	19.1924 mL	95.9619 mL
5 mM	0.3838 mL	1.9192 mL	3.8385 mL	19.1924 mL
10 mM	0.1919 mL	0.9596 mL	1.9192 mL	9.5962 mL
20 mM	0.0960 mL	0.4798 mL	0.9596 mL	4.7981 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0384 mL	0.1919 mL	0.3838 mL	1.9192 mL
100 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.9596 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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