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Beclomethasone 17-propionate

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Beclomethasone 17-propionate

Catalog No. T10494Cas No. 5534-18-9

Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.

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Pack Size	Price	Availability
2 mg	$119	5 days
5 mg	$198	7-10 days
10 mg	$372	7-10 days
25 mg	$788	7-10 days
1 mL x 10 mM (in DMSO)	$198	7-10 days

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Product Introduction

Bioactivity

Description	Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppress
In vitro	Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα, and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα, and CXCL8 were 0.05 nM, 0.01 nM, and 0.1 nM, respectively. Beclomethasone 17-propionate evokes the upregulation of the GR dependent genes FKBP51 and GILZ [3].
Alias	Beclomethasone-17-monopropionate, 17-BMP

Chemical Properties

Molecular Weight	464.98
Formula	C25H33ClO6
Cas No.	5534-18-9

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

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