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Beclomethasone 17-propionate
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Catalog No. T10494Cas No. 5534-18-9
Alias Beclomethasone-17-monopropionate, 17-BMP
Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.
Beclomethasone 17-propionate
😃Good
Catalog No. T10494Alias Beclomethasone-17-monopropionate, 17-BMPCas No. 5534-18-9
Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $119 | 5 days | |
| 5 mg | $198 | 7-10 days | |
| 10 mg | $372 | 7-10 days | |
| 25 mg | $788 | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $198 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppress |
| In vitro | Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα, and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα, and CXCL8 were 0.05 nM, 0.01 nM, and 0.1 nM, respectively. Beclomethasone 17-propionate evokes the upregulation of the GR dependent genes FKBP51 and GILZ [3]. |
| Alias | Beclomethasone-17-monopropionate, 17-BMP |
| Molecular Weight | 464.98 |
| Formula | C25H33ClO6 |
| Cas No. | 5534-18-9 |
| Relative Density. | 1.30 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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