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Bromo-PEG5-phosphonic acid diethyl ester

Name: Bromo-PEG5-phosphonic acid diethyl ester
Brand: TargetMol
SKU: T14809
Price: 151 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T14809Cas No. 1446282-41-2

Bromo-PEG5-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker utilized in the construction of PROteolysis TArgeting Chimeras (PROTACs), which are heterobifunctional molecules designed to induce protein degradation[1].

Bromo-PEG5-phosphonic acid diethyl ester

Catalog No. T14809Cas No. 1446282-41-2

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Product Introduction

Bioactivity

Description	Bromo-PEG5-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker utilized in the construction of PROteolysis TArgeting Chimeras (PROTACs), which are heterobifunctional molecules designed to induce protein degradation[1].
In vitro	PROTACs are composed of two ligands linked together: one targets an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade specific proteins [1].

Chemical Properties

Molecular Weight	465.31
Formula	C₁₆H₃₄BrO₈P
Cas No.	1446282-41-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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