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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $265 | 35 days | |
5 mg | $1,160 | 35 days | |
10 mg | $1,980 | 35 days |
Description | CC-401 is a specific inhibitor of JNK (Ki: 25-50nM). |
In vitro | CC-401 is a second-generation ATP-competitive inhibitor of all three forms of JNK. It is selective against JNK over other kinases such as p38, ERK, IKK2, and ZAP70. CC-401 potently inhibits JNK in cell-based assay with a concentration of 1 to 5μM. The activation of JNK signaling is identified in many immune-mediated kidney disease models. Thus, as the JNK inhibitor, CC-401 is found to be effective in these renal injury models. In the acute anti-GBM disease, CC-401 inhibits JNK activation and causes a 50%-70% reduction of proteinuria. In addition, CC-401 is also used in liver injury models [1][2][3]. |
Molecular Weight | 388.47 |
Formula | C22H24N6O |
Cas No. | 395104-30-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: ≥19.4 mg/mL |
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