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DCG-IV

DCG-IV
DCG-IV is an effective agonist of class II mGluR. DCG-IV has anticonvulsant and neuroprotective effects. The EC50 of mGlu2R and mGlu3R are 0.35 and 0.09 μM, respectively. DCG-IV is also a competitive antagonist of Group I (IC50: mGlu1 / 5R = 389/630 μM) and III receptor (IC50: mGlu4 / 6/7 / 8R = 22.5 / 39.6 / 40.1 / 32 μM).
Catalog No. T10978Cas No. 147782-19-2

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DCG-IV

Catalog No. T10978Cas No. 147782-19-2

DCG-IV is an effective agonist of class II mGluR. DCG-IV has anticonvulsant and neuroprotective effects. The EC50 of mGlu2R and mGlu3R are 0.35 and 0.09 μM, respectively. DCG-IV is also a competitive antagonist of Group I (IC50: mGlu1 / 5R = 389/630 μM) and III receptor (IC50: mGlu4 / 6/7 / 8R = 22.5 / 39.6 / 40.1 / 32 μM).
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Pack SizePriceAvailabilityQuantity
1 mg$74535 days
10 mg$1,59035 days
50 mg$6,41035 days
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Product Introduction

Bioactivity
Description
DCG-IV is an effective agonist of class II mGluR. DCG-IV has anticonvulsant and neuroprotective effects. The EC50 of mGlu2R and mGlu3R are 0.35 and 0.09 μM, respectively. DCG-IV is also a competitive antagonist of Group I (IC50: mGlu1 / 5R = 389/630 μM) a
Targets&IC50
mGluR2R:0.35 μM (EC50), mGluR6:39.6 μM (IC50), mGluR3R:0.09 μM (EC50), mGluR1R:389 μM (IC50), mGluR5:630 μM (IC50), mGluR4R:22.5 μM (IC50), mGluR8:32 μM (IC50), mGluR7:40.1 μM (IC50)
In vitro
DCG-IV is also a NMDA receptor agonist in rat cerebral cortex.
In vivo
DCG-IV (1-10 mg / kg; i.p.) inhibits hyperactivity caused by phencyclidine (PCP).
Chemical Properties
Molecular Weight203.15
FormulaC7H9NO6
Cas No.147782-19-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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