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Desethyl chloroquine diphosphate

Catalog No. T11001L   CAS 247912-76-1

Desethyl chloroquine diphosphate is the main deethyl metabolite of chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Chloroquine diphosphate has anti-plasma activity.

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Desethyl chloroquine diphosphate Chemical Structure
Desethyl chloroquine diphosphate, CAS 247912-76-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Desethyl chloroquine diphosphate is the main deethyl metabolite of chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Chloroquine diphosphate has anti-plasma activity.
In vivo Intraperitoneal injection of chloroquine was used in wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels of chloroquine and its metabolites in blood, brain and muscle tissue. The concentration of chloroquine is low (5-15M), but within 4-24 hours after the last use, it is more stable in brain tissue than blood or muscle. The level of deethylchloroquine, the active chloroquine metabolite in the muscle and blood, decreased 24 hours after injection, while the level of deethylchloroquine in the brain was lower, rising slightly during the same period.
Molecular Weight 487.81
Formula C16H28ClN3O8P2
CAS No. 247912-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. 2. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. 3. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

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Keywords

Desethyl chloroquine diphosphate 247912-76-1 Others Desethyl chloroquine Diphosphate Desethyl chloroquine inhibitor inhibit

 

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