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EN40

EN40, as a covalent ligand, is a selective inhibitor of aldehyde dehydrogenase 3A1 (IC50: 2 uM).

Catalog No. T15217Cas No. 2094547-67-6

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EN40

Catalog No. T15217Cas No. 2094547-67-6

EN40, as a covalent ligand, is a selective inhibitor of aldehyde dehydrogenase 3A1 (IC50: 2 uM).

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Pack Size	Price	Availability
5 mg	$446	6-8 weeks
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,500	6-8 weeks

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Questions

Product Introduction

Bioactivity

Description	EN40, as a covalent ligand, is a selective inhibitor of aldehyde dehydrogenase 3A1 (IC50: 2 uM).
Targets&IC50	ALDH3A1:2 uM
In vitro	EN40 (10-1000 μM; 48 hours) displays an inhibitory effect on ALDH3A1 activity. It also impairs A549 cell survival.
In vivo	EN40 (i.p.; 50mg/kg; from 14 days; once per day) displays strong anti-tumorigenic effects in established A549 tumor xenografts and it also shows good tolerability with no bodyweight loss in mice.

Chemical Properties

Molecular Weight	217.26
Formula	C₁₃H₁₅NO₂
Cas No.	2094547-67-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (23.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6028 mL	23.0139 mL	46.0278 mL	230.1390 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL	46.0278 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL	23.0139 mL
20 mM	0.2301 mL	1.1507 mL	2.3014 mL	11.5070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EN 40EN-40EN40