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Exicorilant

Name: Exicorilant
Brand: TargetMol
SKU: T15264
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T15264Cas No. 1781244-77-6

Alias CORT 125281

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

Exicorilant

Catalog No. T15264Alias CORT 125281Cas No. 1781244-77-6

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

Pack Size	Price	Availability
25 mg	$2,720	10-14 weeks
50 mg	$3,580	10-14 weeks
100 mg	$4,900	10-14 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.
Targets&IC50	GR:（ki）7 nM
In vitro	Exicorilant reverses corticosterone-mediated GR activity in murine brown adipocytes [1].
In vivo	Exicorilant decreases fat mass, body weight, and plasma lipids in HFD-fed mice. Exicorilant (6, 20, or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce fat mass, body weight, plasma TG, cholesterol, and FFA in a dose-dependent manner. But it has no effect on lean mass [2].
Alias	CORT 125281

Chemical Properties

Molecular Weight	589.56
Formula	C₂₆H₂₃F₄N₇O₃S
Cas No.	1781244-77-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (424.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6962 mL	8.4809 mL	16.9618 mL	84.8090 mL
5 mM	0.3392 mL	1.6962 mL	3.3924 mL	16.9618 mL
10 mM	0.1696 mL	0.8481 mL	1.6962 mL	8.4809 mL
20 mM	0.0848 mL	0.4240 mL	0.8481 mL	4.2405 mL
50 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6962 mL
100 mM	0.0170 mL	0.0848 mL	0.1696 mL	0.8481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CORT125281ExicorilantCORT-125281