Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GB-88 is an selective , oral non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM.
Description | GB-88 is an selective , oral non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM. |
In vitro | GB-88 inhibits iCa2+ release induced in HT29 cells by trypsin, 2f-LIGRLO-NH2 and GB110 (PAR2 agonists).?And antagonism by GB-88 is agonist dependent. |
In vivo | GB-88 inhibits PAR2-induced acute inflammation in vivo.GB-88 is both orally active and anti-inflammatory in vivo, with specific antagonist activity against four structurally and mechanistically different PAR2 agonists (2f-LIGRLO-NH2, trypsin, SLIGRL-NH2 and GB110). |
Molecular Weight | 546.7 |
Formula | C32H42N4O4 |
CAS No. | 1416435-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (57.16 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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GB-88 1416435-96-5 Others GB 88 GB88 inhibitor inhibit