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GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9). |
Targets&IC50 | EP1 receptor:7.9 (pic50) |
In vitro | GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE2 dose-response curve and Schild analysis displays that GSK-269984A is a competitive antagonist with pA2 8.1±0.3 and slope 1.0[1]. |
In vivo | GSK-269984A(10 mg/kg,p.o.) treatment, showing equivalent reversal of hypersensitivity to the standard(ED50: 2.6 mg/kg). GSK-269984A displays moderate blood clearance in the rat and dog and high clearance in the monkey which is reflected in the half-life for each species[1]. |
Molecular Weight | 429.22 |
Formula | C20H14Cl2FNNaO3 |
Cas No. | 892664-04-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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