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Hyodeoxycholic acid sodium salt

Catalog No. T2968L CAS 10421-49-5

Synonyms: Sodium hyodeoxycholate, HDCA sodium

Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 synthesis.

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Hyodeoxycholic acid sodium salt Chemical Structure

Hyodeoxycholic acid sodium salt, CAS 10421-49-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Sodium hyodeoxycholate, HDCA sodium
Molecular Weight	415.56
Formula	C24H40NaO4
CAS No.	10421-49-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Peng LQ, Cao J, Du LJ, Zhang QD, Xu JJ, Chen YB, Shi YT, Li RR. Rapid ultrasonic and microwave-assisted micellar extraction of zingiberone, shogaol and gingerols from gingers using biosurfactants. J Chromatogr A. 2017 Sep 15;1515:37-44. doi: 10.1016/j.chroma.2017.07.092. Epub 2017 Aug 1. PubMed PMID: 28789800. 2. Zhao DS, Jiang LL, Fan YX, Dong LC, Ma J, Dong X, Xu XJ, Li P, Li HJ. Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. Food Chem Toxicol. 2017 Oct;108(Pt B):532-542. doi: 10.1016/j.fct.2017.02.030. Epub 2017 Feb 24. PubMed PMID: 28237774. 3. Fu ZD, Klaassen CD. Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):680-90. doi: 10.1016/j.taap.2013.10.020. Epub 2013 Oct 29. PubMed PMID: 24183703; PubMed Central PMCID: PMC4132937. 4. Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochem Pharmacol. 2013 Aug 1;86(3):437-45. doi: 10.1016/j.bcp.2013.05.020. Epub 2013 Jun 6. PubMed PMID: 23747753; PubMed Central PMCID: PMC3774164.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hyodeoxycholic acid sodium salt 10421-49-5 Hyodeoxycholic acid sodium Sodium hyodeoxycholate HDCA sodium inhibitor inhibit

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