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MK-4074

Name: MK-4074
Brand: TargetMol
SKU: T12062
Price: 117 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T12062Cas No. 1039758-22-9

MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.

MK-4074

Catalog No. T12062Cas No. 1039758-22-9

MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.

Pack Size	Price	Availability
25 mg	$1,980	10-14 weeks
50 mg	$2,698	10-14 weeks
100 mg	Inquiry	10-14 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.
Targets&IC50	ACC1:3 nM
In vitro	MK-4074 is highly liver specific because it is a substrate of organic anion transport protein (OATP) transporters that are present only in hepatocytes, and excretion of MK-4074 from hepatocytes into bile is dependent on the MRP2 efflux transporter[1].
In vivo	MK-4074 orally at 30 mg/kg reduces hepatic DNL by 83%, 70%, and 51% at 4, 8, and 12 hr post-dose, respectively. Single oral doses of MK-4074 at 30 and 100 mg/kg significantly increases plasma total ketones, a surrogate biomarker for hepatic FAO, by 1.5-fold to 3-fold for up to 8 hr[1].

Chemical Properties

Molecular Weight	565.62
Formula	C₃₃H₃₁N₃O₆
Cas No.	1039758-22-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 83.3 mg/mL (147.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7680 mL	8.8399 mL	17.6797 mL	88.3986 mL
5 mM	0.3536 mL	1.7680 mL	3.5359 mL	17.6797 mL
10 mM	0.1768 mL	0.8840 mL	1.7680 mL	8.8399 mL
20 mM	0.0884 mL	0.4420 mL	0.8840 mL	4.4199 mL
50 mM	0.0354 mL	0.1768 mL	0.3536 mL	1.7680 mL
100 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK4074MK 4074MK-4074