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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $987 | 35 days |
Description | MS 39 is a highly effective, highly affinity and selective depressant of mutant epidermal growth factor receptor (EGFR) with high efficiency, high affinity and selectivity. MS 39, conjured by gefitinib to VHL ligand via a linker, effectively induced the degradation of mutant EGFR (DC50 values in HCC827(exon 19 del) and H3255 (L858R mutation) lung cancer cell lines were 5 nM and 3.3 nM, respectively). However, there was no significant effect in wild-type EGFR cell lines with concentrations up to 10 μM. MS 39 inhibited the proliferation of H3255 lung cancer cells in vitro and was bioavailable in mice after administration. |
Molecular Weight | 1056.72 |
Formula | C55H71ClFN9O7S |
Cas No. | 2675490-92-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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