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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $916 | 6-8 weeks | |
50 mg | $1,190 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks |
Description | Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. |
In vitro | Mivotilate has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate is a nontoxic and potent activator of the aryl hydrocarbon receptor. Mivotilate causes cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3]. |
In vivo | Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats, and at doses of 75-300 mg/kg, it rapidly decreases immunoreactive CYP2E1 protein. Additionally, Mivotilate (150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats without significantly affecting NADPH-dependent P450 oxidoreductase activity [2]. |
Alias | YH439 |
Molecular Weight | 330.45 |
Formula | C12H14N2O3S3 |
Cas No. | 130112-42-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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