Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 |
Description | MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM). |
Targets&IC50 | WT MtbHU:(kd)98 nM |
In vitro | MtbHU-IN-1 (SD4) is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with Kds of 98 nM, 760 nM, 980 nM, 340 nM and 730 nM for WT and mutant MtbHUs, respectively.Specifically inhibit HU-DNA binding, disrupt nucleoid architecture and reduce Mtb growth. The stilbene inhibitors induce gene expression changes in Mtb that resemble those induced by HU deficiency. Indicate that HU is a potential target for the development of therapies against tuberculosis[1]. |
Molecular Weight | 876.91 |
Formula | C44H36N4O12S2 |
CAS No. | 59736-84-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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MtbHU-IN-1 59736-84-4 Others MtbHU IN 1 MtbHUIN1 inhibitor inhibit