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NMS-P515

Catalog No. T16334Cas No. 1262395-13-0

NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.

NMS-P515

NMS-P515

Catalog No. T16334Cas No. 1262395-13-0
NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.
Pack SizePriceAvailabilityQuantity
25 mg$1,3108-10 weeks
50 mg$1,7108-10 weeks
100 mg$2,5908-10 weeks
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Product Introduction

Bioactivity
Description
NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.
Targets&IC50
PARP1:16 nM (kd), PARP1:27 nM (in Hela cells)
In vivo
NMS-P515 (80 mg/kg; p.o.; 12 days) shows effective antitumor activity in mouse models based on pancreatic cancer.
Chemical Properties
Molecular Weight355.47
FormulaC21H29N3O2
Cas No.1262395-13-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

NMS P515NMS-P515NMS-P-515NMSP515NMS-P 515
Related Tags: buy NMS-P515 | purchase NMS-P515 | NMS-P515 cost | order NMS-P515 | NMS-P515 chemical structure | NMS-P515 in vivo | NMS-P515 formula | NMS-P515 molecular weight
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