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RPH-2823

Name: RPH-2823
Brand: TargetMol
SKU: T19552
Price: 148 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T19552Cas No. 96558-24-6

RPH-2823, a basic amphotericin analog, is diuretic, natriuretic, and potassium-preserving, inducing a dose-dependent decrease in SCC and an increase in trans-epithelial resistance.

RPH-2823

Purity: 99.67%

Catalog No. T19552Cas No. 96558-24-6

RPH-2823, a basic amphotericin analog, is diuretic, natriuretic, and potassium-preserving, inducing a dose-dependent decrease in SCC and an increase in trans-epithelial resistance.

Pack Size	Price	Availability
1 mg	$293	6-8 weeks
5 mg	$736	6-8 weeks
10 mg	$987	6-8 weeks
25 mg	$1,490	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Purity:99.67%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	RPH-2823, a basic amphotericin analog, is diuretic, natriuretic, and potassium-preserving, inducing a dose-dependent decrease in SCC and an increase in trans-epithelial resistance.
In vitro	Interacting with the Na+ channel or a regulator site within the apical membrane, RPH-2823 influences transepithelial Na+ transport[2].
In vivo	Avoiding the kaliuresis of 25 mumol/kg furosemide in male Wistar rats, RPH 2823 (2.5 mumol/kg) demonstrates its efficacy. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) exhibits a terminal elimination half-life of 3 h, with approximately 47% of the administered dose being excreted unchanged in the urine[1].

Chemical Properties

Molecular Weight	370.41
Formula	C₁₇H₂₂N₈O₂
Cas No.	96558-24-6

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RPH 2823RPH-2823RPH2823