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Riviciclib

Name: Riviciclib
Brand: TargetMol
SKU: T12737
Price: 39 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T12737Cas No. 920113-02-6

Alias P276-00 (free base)

Riviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.

Riviciclib

Catalog No. T12737Alias P276-00 (free base)Cas No. 920113-02-6

Pack Size	Price	Availability
25 mg	$1,820	1-2 weeks
50 mg	$2,380	1-2 weeks
100 mg	$3,100	1-2 weeks

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Product Introduction

Bioactivity

Description	Riviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.
Targets&IC50	CDK4-CyclinD1:0.063 μM, CDK2-CyclinE:2.540 μM, CDK6-CyclinD1:0.396 μM, CDK1-CyclinB:0.079 μM, CDK2-CyclinA:0.224 μM, CDK9-CyclinH:2.900 μM, CDK9-CyclinT1:0.020 μM
In vitro	Riviciclib (3-24 hours; 1.5 μM) reduces cyclin D1, Cdk4, and Rb levels in H-460 cells. Rb (retinoblastoma) phosphorylation at Ser780 decrease at 3 h. Riviciclib shows activity in human cancer cell lines, such as colon carcinoma, osteosarcomal, cervical carcinoma, and bladder carcinoma cells[2].Riviciclib shows no detectable cells in G1 and G2 in promyelocytic leukemia cells and arrest of cells in G1 in synchronized human non-small cell lung carcinoma (H-460) and human normal lung fibroblast (WI-38) cells[3].
In vivo	Riviciclib in human xenograft mode with severe combined immunodeficient mice shows significant inhibition in the growth of human colon carcinoma HCT-116 xenograft[3].
Alias	P276-00 (free base)

Chemical Properties

Molecular Weight	401.84
Formula	C₂₁H₂₀ClNO₅
Cas No.	920113-02-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

P276-00Riviciclib