Shopping Cart

Remove All

Your shopping cart is currently empty

SAR7334 hydrochloride

Resource Download

SAR7334 hydrochloride

Catalog No. T12849LCas No. 1333207-63-8

SAR7334 hydrochloride is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$189	In Stock
10 mg	$263	In Stock
25 mg	$373	In Stock
50 mg	$488	In Stock
100 mg	$619	In Stock
200 mg	$877	In Stock
500 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	SAR7334 hydrochloride is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
In vitro	SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226?nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents[3].
In vivo	In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

Chemical Properties

Molecular Weight	440.79
Formula	C21H24Cl3N3O
Cas No.	1333207-63-8

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (226.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2687 mL	11.3433 mL	22.6865 mL	113.4327 mL
5 mM	0.4537 mL	2.2687 mL	4.5373 mL	22.6865 mL
10 mM	0.2269 mL	1.1343 mL	2.2687 mL	11.3433 mL
20 mM	0.1134 mL	0.5672 mL	1.1343 mL	5.6716 mL
50 mM	0.0454 mL	0.2269 mL	0.4537 mL	2.2687 mL
100 mM	0.0227 mL	0.1134 mL	0.2269 mL	1.1343 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SAR 7334 HydrochlorideSAR7334 HydrochlorideSAR7334 hydrochlorideSAR-7334 HydrochlorideSAR-7334 hydrochloride