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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $65 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $263 | In Stock | |
25 mg | $425 | In Stock | |
50 mg | $597 | In Stock | |
100 mg | $747 | In Stock | |
1 mL x 10 mM (in DMSO) | $178 | In Stock |
Description | SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). |
Targets&IC50 | TRPC6:7.9 nM |
In vitro | SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3]. |
In vivo | In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
Alias | TRCP6-IN-1 |
Molecular Weight | 367.87 |
Formula | C21H22ClN3O |
Cas No. | 1333210-07-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 350 mg/mL (951.42 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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