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SAR7334 hydrochloride

SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.

Catalog No. T12849LCas No. 1333207-63-8

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SAR7334 hydrochloride

Catalog No. T12849LCas No. 1333207-63-8

SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$113	In Stock
10 mg	$158	In Stock
25 mg	$223	In Stock
50 mg	$293	In Stock
100 mg	$371	In Stock
200 mg	$526	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

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Product Introduction

Bioactivity

Description	SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.
Targets&IC50	TRPC6 current:7.9 nM
In vitro	SAR7334 inhibits TRPC6, TRPC3, and TRPC7-mediated Ca2+ influx into cells (IC50s of 9.5, 282, and 226 nM, respectively) [1][2][3], while TRPC4 and TRPC5-mediated Ca2+ entry remains unaffected. At 1 μM, SAR7334 significantly blocks Ang II-evoked calcium influx in podocytes [1]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM, and at 100 nM, it substantially reduces TRPC6 currents [3].
In vivo	In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

Chemical Properties

Molecular Weight	440.79
Formula	C₂₁H₂₄Cl₃N₃O
Cas No.	1333207-63-8

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (226.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2687 mL	11.3433 mL	22.6865 mL	113.4327 mL
5 mM	0.4537 mL	2.2687 mL	4.5373 mL	22.6865 mL
10 mM	0.2269 mL	1.1343 mL	2.2687 mL	11.3433 mL
20 mM	0.1134 mL	0.5672 mL	1.1343 mL	5.6716 mL
50 mM	0.0454 mL	0.2269 mL	0.4537 mL	2.2687 mL
100 mM	0.0227 mL	0.1134 mL	0.2269 mL	1.1343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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