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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,890 | Backorder | |
1 mL x 10 mM (in DMSO) | $2,289 | Backorder |
Description | Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide. |
In vitro | Root cultures of Senecio erucifolius (Asteraceae) efficiently took up and incorporated [14C]putrescine and [14C]arginine into the pyrrolizidine alkaloid (PA) senecionine N-oxide. Pulse-chase experiments covering a growth period of 10 to 19 days revealed the absence of any significant alkaloid turnover[1] |
In vivo | Seneciphylline was quickly absorbed into plasma (Tmax , 0.23-0.32 h) and reached the maximum concentration of 0.82-1.75 μg/mL after oral administration. Both seneciphylline and seneciphylline N-oxide were eliminated from plasma quickly. The low system exposure (oral bioavailability, 5.43-10.31%) was related to the extensive metabolism in the liver and microflora.[2] |
Molecular Weight | 349.38 |
Formula | C18H23NO6 |
Cas No. | 38710-26-8 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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