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Seneciphylline N-oxide

Seneciphylline N-oxide
Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.
Catalog No. TN2204Cas No. 38710-26-8
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Seneciphylline N-oxide

Catalog No. TN2204Cas No. 38710-26-8

Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.
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5 mg$1,890Backorder
1 mL x 10 mM (in DMSO)$2,289Backorder
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Product Introduction

Bioactivity
Description
Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.
In vitro
Root cultures of Senecio erucifolius (Asteraceae) efficiently took up and incorporated [14C]putrescine and [14C]arginine into the pyrrolizidine alkaloid (PA) senecionine N-oxide. Pulse-chase experiments covering a growth period of 10 to 19 days revealed the absence of any significant alkaloid turnover[1]
In vivo
Seneciphylline was quickly absorbed into plasma (Tmax , 0.23-0.32 h) and reached the maximum concentration of 0.82-1.75 μg/mL after oral administration. Both seneciphylline and seneciphylline N-oxide were eliminated from plasma quickly. The low system exposure (oral bioavailability, 5.43-10.31%) was related to the extensive metabolism in the liver and microflora.[2]
Chemical Properties
Molecular Weight349.38
FormulaC18H23NO6
Cas No.38710-26-8
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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