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VHL Ligand-Linker Conjugates 17

Catalog No. T18873 CAS T18873

VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].

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VHL Ligand-Linker Conjugates 17 Chemical Structure

VHL Ligand-Linker Conjugates 17, CAS T18873

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	654.75
Formula	C37H42N4O7
CAS No.	T18873

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Han X, Zhao L, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

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Keywords

VHL Ligand-Linker Conjugates 17 T18873 Others VHL LigandLinker Conjugates 17 VHL Ligand Linker Conjugates 17 inhibitor inhibit

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