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ZM 449829

Catalog No. T23564Cas No. 4452-06-6

ZM 449829 is an effective, selective inhibitor of Janus tyrosine kinase 3 which binds competitively to the JAK3 ATP site (pIC50: 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively).

ZM 449829

ZM 449829

Catalog No. T23564Cas No. 4452-06-6
ZM 449829 is an effective, selective inhibitor of Janus tyrosine kinase 3 which binds competitively to the JAK3 ATP site (pIC50: 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively).
Pack SizePriceAvailabilityQuantity
5 mg$21535 days
10 mg$38035 days
25 mg$89035 days
50 mg$1,67035 days
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Product Introduction

Bioactivity
Description
ZM 449829 is an effective, selective inhibitor of Janus tyrosine kinase 3 which binds competitively to the JAK3 ATP site (pIC50: 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively).
Chemical Properties
Molecular Weight182.222
FormulaC13H10O
Cas No.4452-06-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: ≥8.2 mg/mL
Ethanol: <1 mg/mL
H2O: <1 mg/mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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