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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $297 | 6-8 weeks | |
25 mg | $987 | 6-8 weeks | |
50 mg | $1,360 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $365 | 6-8 weeks |
Description | ZYZ-488 is a competitive inhibitor of apoptotic protease activating factor-1 (Apaf-1). |
In vitro | In hypoxic H9c2 cells, ZYZ-488 reduces apoptosis by inhibiting the hypoxia-induced activation of Apaf-1, which mediates the activation of procaspase-9 and procaspase-3. Additionally, ZYZ-488 diminishes the release of myocardial enzymes, prevents cardiomyocyte apoptosis, and suppresses the activation of the downstream caspase cascade. |
In vivo | ZYZ-488 protected against myocardial apoptosis. |
Molecular Weight | 487.46 |
Formula | C20H29N3O11 |
Cas No. | 1470302-79-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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