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[D-Trp11]-Neurotensin

Name: [D-Trp11]-Neurotensin
Brand: TargetMol
SKU: T40850
Price: 33 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T40850Cas No. 73634-68-1

Alias [D-Trp11]-Neurotensin

[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.

[D-Trp11]-Neurotensin

Catalog No. T40850Alias [D-Trp11]-NeurotensinCas No. 73634-68-1

Pack Size	Price	Availability	Quantity
5 mg	$970	Backorder

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Product Introduction

Bioactivity

Description	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
In vitro	[D-Trp11]-Neurotensin significantly reduces neurotensin (NT)-induced coronary vessel constriction in perfused rat hearts at concentrations ranging from 0.13 to 1.1 µM. Additionally, at higher concentrations (2-110 µM), [D-Trp11]-Neurotensin demonstrates neurotensin-like activity in the same experimental setup[1].
In vivo	[D-Trp11]-Neurotensin administered intravenously at doses ranging from 50 to 500 nmol/kg induces hypotensive effects in rats anesthetized with pentobarbital, exhibiting an effective dose (ED 25) of 122 nmol/kg.
Alias	[D-Trp11]-Neurotensin

Chemical Properties

Molecular Weight	1695.991
Formula	C₈₀H₁₂₂N₂₂O₁₉
Cas No.	73634-68-1

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

[DTrp11]Neurotensin[D-Trp-11]-Neurotensin[D Trp11] Neurotensin