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A-317491 sodium salt hydrate
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Catalog No. T10204
Alias A-317491 sodium salt hydrate (475205-49-3 free base)
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.
A-317491 sodium salt hydrate
😃Good
Catalog No. T10204Alias A-317491 sodium salt hydrate (475205-49-3 free base)
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $87 | Backorder | |
| 10 mg | $127 | Backorder | |
| 50 mg | $423 | Backorder | |
| 100 mg | Inquiry | Backorder | |
| 200 mg | Inquiry | Backorder | |
| 1 mL x 10 mM (in DMSO) | $115 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux. |
| In vitro | A-317491 is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. The P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management. |
| Alias | A-317491 sodium salt hydrate (475205-49-3 free base) |
| Molecular Weight | 606.57 |
| Formula | C33H29NNaO9 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (164.86 mM) H2O: 100 mg/mL (164.86 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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