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AACA, an inhibitor for sclerostin, binds to the loop3 region of sclerostin with a Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through the Wnt signaling pathway [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | AACA, an inhibitor for sclerostin, binds to the loop3 region of sclerostin with a Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through the Wnt signaling pathway [1]. |
In vitro | AACA (10 μM, 12 h) activates the Wnt signaling pathway inhibited by osteocalcin, leading to increased expression of bone formation markers [1]. In the cell line MC3T3-E1, with a concentration of 10 μM and an incubation time of 12 hours, there is an upregulation of mRNA levels for bone formation markers ALP and OCN, as shown by Real Time qPCR [1]. |
Molecular Weight | 274.27 |
Formula | C14H14N2O4 |
Cas No. | 2515609-54-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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