Shopping Cart

Remove All
Your shopping cart is currently empty

Abetimus

Name: Abetimus
Brand: TargetMol
SKU: T83217
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T83217Cas No. 167362-48-3

Alias LJP 394 free base

Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].

Abetimus

😃Good

Catalog No. T83217Alias LJP 394 free baseCas No. 167362-48-3

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
In vitro	The administration of Abetimus (LJP 394 free base) is believed to reduce circulating anti-double-stranded DNA antibodies (anti-dsDNA Abs) via at least two mechanisms.
In vivo	Abetimus (LJP 394 free base) effectively reduces anti-dsDNA-mediated disease symptoms in male BXSB mice, a systemic lupus model. Administering Abetimus at 3-300 μg/mouse intravenously twice weekly from around nine weeks of age significantly lowered anti-dsDNA antibody levels, decreased anti-dsDNA-secreting spleen cells, and improved renal histopathology compared to untreated controls [2]. Additionally, Abetimus exhibits a pharmacokinetic half-life of 40 minutes to 1 hour in mice [1].
Alias	LJP 394 free base

Chemical Properties

Molecular Weight	318.28
Formula	C₁₁H₁₈N₄O₇
Cas No.	167362-48-3

Storage & Solubility Information

Storage

Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc