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Abetimus

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Catalog No. T83217Cas No. 167362-48-3
Alias LJP 394 free base

Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].

Abetimus

Abetimus

😃Good
Catalog No. T83217Alias LJP 394 free baseCas No. 167362-48-3
Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
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5 mgInquiry8-10 weeks
50 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
In vitro
The administration of Abetimus (LJP 394 free base) is believed to reduce circulating anti-double-stranded DNA antibodies (anti-dsDNA Abs) via at least two mechanisms.
In vivo
Abetimus (LJP 394 free base) effectively reduces anti-dsDNA-mediated disease symptoms in male BXSB mice, a systemic lupus model. Administering Abetimus at 3-300 μg/mouse intravenously twice weekly from around nine weeks of age significantly lowered anti-dsDNA antibody levels, decreased anti-dsDNA-secreting spleen cells, and improved renal histopathology compared to untreated controls [2]. Additionally, Abetimus exhibits a pharmacokinetic half-life of 40 minutes to 1 hour in mice [1].
AliasLJP 394 free base
Chemical Properties
Molecular Weight318.28
FormulaC11H18N4O7
Cas No.167362-48-3
Storage & Solubility Information
StorageShipping with blue ice.

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