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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1]. |
In vitro | Administration of Abetimus (LJP 394 free base) is believed to decrease circulating anti-double-stranded DNA antibodies (anti-dsDNA Abs) through at least two mechanisms. |
In vivo | Abetimus (LJP 394 free base) demonstrates efficacy in diminishing anti-dsDNA-mediated disease manifestations in the male BXSB mouse, which serves as a model for systemic lupus. Administration of Abetimus at dosages between 3-300 μg/mouse intravenously twice weekly from approximately nine weeks of age resulted in significantly reduced anti-dsDNA antibody titers, a decreased number of anti-dsDNA-secreting spleen cells, and improved renal histopathology compared to untreated controls [2]. Additionally, the pharmacokinetic profile of Abetimus in mice displays a half-life of 40 minutes to 1 hour [1]. |
Alias | LJP 394 free base |
Molecular Weight | 318.28 |
Formula | C11H18N4O7 |
Cas No. | 167362-48-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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