Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibits neutrophil extravasation and demonstrates antimigratory effects by attenuating the recruitment of neutrophils in experimental models of inflammation [1] [2].

Ac2-12 TFA, administered intravenously at a dosage of 6.7 mg/kg (approximately 70 nmol per mouse), emulates the effects of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice weighing 10-15 grams [1]. Furthermore, a 100 μg dose notably diminishes polymorphonuclear leukocyte (PMN) infiltration in C57BL/6 wild-type mice, while it lacks efficacy in FPR knockout (KO) mice [2].