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AI-10-104 acts as an inhibitor of the runt-related transcription factor (RUNX), increasing cytotoxic effects in myeloma cells [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | AI-10-104 acts as an inhibitor of the runt-related transcription factor (RUNX), increasing cytotoxic effects in myeloma cells [1]. |
In vitro | AI-10-104 (0-10 μM) inhibits RUNX by dissociating the RUNXs-IKZFs complex, thereby enhancing the antiproliferative and cytotoxic effects of lenalidomide (CC-5013) on myeloma cells [1]. Western Blot analysis [1], using a concentration of 0-10 μM in HEK293T cells, shows a reduction in IKZF3 and CBFβ levels. Cell proliferation assays [1] conducted on OPM-1, KMS-11, and U266 cell lines at a concentration of 1 μM revealed maintained cell viability with moderate inhibition of OPM-1 cell proliferation. |
Molecular Weight | 309.24 |
Formula | C14H10F3N3O2 |
Cas No. | 1881276-00-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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