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Aldumastat

Name: Aldumastat
Brand: TargetMol
SKU: T35859
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T35859Cas No. 1957278-93-1

Alias S201086, GLPG1972, G504572

Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.

Aldumastat

🥰Excellent

Purity: 99.87%

Catalog No. T35859Alias S201086, GLPG1972, G504572Cas No. 1957278-93-1

Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.

Pack Size	Price	Availability	Quantity
1 mg	$299	In Stock

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Purity:99.87%

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COA LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.
Targets&IC50	MMP2:1158 nM, ADAMTS-5:19 nM, ADAMTS-4:156 nM, MMP14:>3198 nM
In vivo	Aldumastat (GLPG1972;1mg/kg i.v./5mg/kg p.o.) displayed favorable pharmacokinetic profiles in mice, rats, and dogs, with oral bioavailability of 25%, 58%, and 97%, respectively.[1].
Alias	S201086, GLPG1972, G504572

Chemical Properties

Molecular Weight	406.43
Formula	C₂₀H₂₄F₂N₄O₃
Cas No.	1957278-93-1
Smiles	C[C@H]1CN(CCN1c1cc(F)cc(F)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (222.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4604 mL	12.3022 mL	24.6045 mL	123.0224 mL
5 mM	0.4921 mL	2.4604 mL	4.9209 mL	24.6045 mL
10 mM	0.2460 mL	1.2302 mL	2.4604 mL	12.3022 mL
20 mM	0.1230 mL	0.6151 mL	1.2302 mL	6.1511 mL
50 mM	0.0492 mL	0.2460 mL	0.4921 mL	2.4604 mL
100 mM	0.0246 mL	0.1230 mL	0.2460 mL	1.2302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AldumastatADAMTS-5