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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $299 | In Stock |
Description | Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee. |
Targets&IC50 | MMP14:>3198 nM, ADAMTS-5:19 nM, ADAMTS-4:156 nM, MMP2:1158 nM |
In vivo | Aldumastat (GLPG1972;1mg/kg i.v./5mg/kg p.o.) displayed favorable pharmacokinetic profiles in mice, rats, and dogs, with oral bioavailability of 25%, 58%, and 97%, respectively.[1]. |
Alias | GLPG1972, S201086, G504572 |
Molecular Weight | 406.43 |
Formula | C20H24F2N4O3 |
Cas No. | 1957278-93-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (222.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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