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anti-TNBC agent-1

Catalog No. T39815 CAS 2289585-58-4

anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.

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anti-TNBC agent-1, CAS 2289585-58-4

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25 mg	Inquiry	$ 1,520.00

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Description

In vitro

Anti-TNBC agent-1 (compound 7) demonstrates significant efficacy against a range of breast cancer cell lines, including MDA-MB231, SUM-159, MCF-7, Bcap-37, and 4T1. The compound achieves IC50 values between 0.20 µM to 0.27 µM, indicating a 11.6- to 18.6-fold enhancement in potency relative to its progenitor, parthenolide, which has IC50 values between 2.68 µM and 4.63 µM. Notably, anti-TNBC agent-1 surpasses the effectiveness of the benchmark drug Adriamycin (ADR)[1]. Specifically, at concentrations of 2 µM and 5 µM over 48 hours, it significantly increases apoptosis induction in SUM-159 cells compared to parthenolide[1], establishing its superior therapeutic potential. Moreover, anti-TNBC agent-1 exhibits selective cytotoxicity towards breast cancer cells, with an IC50 of 0.22 µM, as opposed to the negligible effect on 3T3 cells (IC50 = 8.13 µM)[1], underscoring its specificity and promising profile as a targeted anti-TNBC therapy.

Molecular Weight	454.519
Formula	C26H30O7
CAS No.	2289585-58-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ge W, et al. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469.

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Keywords

anti-TNBC agent-1 2289585-58-4 anti TNBC agent 1 antiTNBC agent1 inhibitor inhibit

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