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Anti-JAM2 Monoclonal Antibody-AF488
Catalog No. TMAZ-0270A4
Alias Vascular endothelial junction-associated molecule, Junctional adhesion molecule B, Junctional adhesion molecule 2
Anti-JAM2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-JAM2 Monoclonal Antibody-AF488
Anti-JAM2 Monoclonal Antibody-AF488
Catalog No. TMAZ-0270A4Alias Vascular endothelial junction-associated molecule, Junctional adhesion molecule B, Junctional adhesion molecule 2
Anti-JAM2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $370 | 12 days | |
| 50 μg | $610 | 12 days | |
| 100 μg | $915 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-JAM2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting JAM2. Anti-JAM2 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | Vascular endothelial junction-associated molecule, Junctional adhesion molecule B, Junctional adhesion molecule 2 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of JAM2 overexpressed 467F cells with TMAZ-0270A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of JAM2 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed: 11590146, PubMed: 11823489, PubMed: 24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed: 24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed: 11590146, PubMed: 24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed: 12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed: 12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | JAM2 |
| Antigen Species | Human |
| Gene ID | 58494 |
| Uniprot ID | |
| Biology Area | Other Functions |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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