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HTT-D3

🥰Excellent
Catalog No. T61991Cas No. 2254502-89-9
Alias HTTD3

HTT-D3 is an orally active, highly efficient Huntington splicing modulator. It induces HTT mRNA degradation, reduces HTT protein levels, and inhibits P-glycoprotein (P-gp) efflux. This compound can be used in Huntington's disease research.

HTT-D3

HTT-D3

🥰Excellent
Purity: 99.31%
Catalog No. T61991Alias HTTD3Cas No. 2254502-89-9
HTT-D3 is an orally active, highly efficient Huntington splicing modulator. It induces HTT mRNA degradation, reduces HTT protein levels, and inhibits P-glycoprotein (P-gp) efflux. This compound can be used in Huntington's disease research.
Pack SizePriceAvailabilityQuantity
1 mg$293In Stock
5 mg$722In Stock
10 mg$987In Stock
25 mg$1,520In Stock
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Purity:99.31%
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Product Introduction

Bioactivity
Description
HTT-D3 is an orally active, highly efficient Huntington splicing modulator. It induces HTT mRNA degradation, reduces HTT protein levels, and inhibits P-glycoprotein (P-gp) efflux. This compound can be used in Huntington's disease research.
AliasHTTD3
Chemical Properties
Molecular Weight404.48
FormulaC23H25FN6
Cas No.2254502-89-9
SmilesFC1=CC(=CC=2N=NC(=CC12)C3CCN(CC)CC3)C4=NN5C=C(N=C5C(=C4)C)C
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 0.625 mg/mL (insoluble or slightly soluble)
DMSO: 0.71 mg/mL (1.76 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4723 mL12.3616 mL24.7231 mL123.6155 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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