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Anticancer agent 199
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Catalog No. T85676Cas No. 2422001-24-7
Anticancer agent 199 (Compound G-4) is a derivative of the cyclin-dependent kinase inhibitor Rocovitine [1]. It prompts apoptosis in triple negative breast cancer (TNBC) cells through the mitochondrial pathway by inhibiting the EGFR, AKT, and MAPK pathways. Furthermore, it triggers Ferroptosis by suppressing LCN2 and reduces TNBC cell viability and migration while inducing S phase cell cycle arrest.
Anticancer agent 199
😃Good
Catalog No. T85676Cas No. 2422001-24-7
Anticancer agent 199 (Compound G-4) is a derivative of the cyclin-dependent kinase inhibitor Rocovitine [1]. It prompts apoptosis in triple negative breast cancer (TNBC) cells through the mitochondrial pathway by inhibiting the EGFR, AKT, and MAPK pathways. Furthermore, it triggers Ferroptosis by suppressing LCN2 and reduces TNBC cell viability and migration while inducing S phase cell cycle arrest.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Bioactivity
Chemical Properties
| Description | Anticancer agent 199 (Compound G-4) is a derivative of the cyclin-dependent kinase inhibitor Rocovitine [1]. It prompts apoptosis in triple negative breast cancer (TNBC) cells through the mitochondrial pathway by inhibiting the EGFR, AKT, and MAPK pathways. Furthermore, it triggers Ferroptosis by suppressing LCN2 and reduces TNBC cell viability and migration while inducing S phase cell cycle arrest. |
| Molecular Weight | 556.12 |
| Formula | C29H39ClFN7O |
| Cas No. | 2422001-24-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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