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Antimalarial agent 38

Catalog No. T88148Cas No. 123580-46-1

Antimalarial agent 38 (Compound 1) demonstrates antiplasmodial activity by inhibiting multiple strains of Plasmodium falciparum, including the D6 strain, chloroquine-sensitive Thai strain, and chloroquine-resistant FcB1 and K1 strains, with IC 50 values of 0.5, 13, 1, and 13 μM, respectively. This compound is non-cytotoxic to mammalian cells MCR58 (IC 50 >140 μM) and enhances the survival rate in a Plasmodium yoelii nigeriensis-infected mouse model.

Antimalarial agent 38

Antimalarial agent 38

Catalog No. T88148Cas No. 123580-46-1
Antimalarial agent 38 (Compound 1) demonstrates antiplasmodial activity by inhibiting multiple strains of Plasmodium falciparum, including the D6 strain, chloroquine-sensitive Thai strain, and chloroquine-resistant FcB1 and K1 strains, with IC 50 values of 0.5, 13, 1, and 13 μM, respectively. This compound is non-cytotoxic to mammalian cells MCR58 (IC 50 >140 μM) and enhances the survival rate in a Plasmodium yoelii nigeriensis-infected mouse model.
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Product Introduction

Bioactivity
Description
Antimalarial agent 38 (Compound 1) demonstrates antiplasmodial activity by inhibiting multiple strains of Plasmodium falciparum, including the D6 strain, chloroquine-sensitive Thai strain, and chloroquine-resistant FcB1 and K1 strains, with IC 50 values of 0.5, 13, 1, and 13 μM, respectively. This compound is non-cytotoxic to mammalian cells MCR58 (IC 50 >140 μM) and enhances the survival rate in a Plasmodium yoelii nigeriensis-infected mouse model.
Chemical Properties
Molecular Weight692.71
FormulaC36H40N2O12
Cas No.123580-46-1
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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