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Antisauvagine-30 TFA (220673-95-0 free base)

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Antisauvagine-30 TFA (220673-95-0 free base)

Catalog No. T10338

Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

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Pack Size	Price	Availability	Quantity
1 mg	$531	Backorder
5 mg	$1,586	Backorder

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Product Introduction

Bioactivity

Description	Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
Targets&IC50	CRFR2β (mouse):(kd)1.4 nM , CRFR1:150 nM (kd)
In vitro	Antisauvagine-30 prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. It did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice [1][2].
In vivo	Antisauvagine-30 (i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2]. Antisauvagine-30 injected i.c.v. elicits a significant anxiogenic effect [3].
Alias	Antisauvagine-30 TFA, aSvg-30 TFA

Chemical Properties

Molecular Weight	3764.28
Formula	C163H275N48F3O49S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Keywords

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