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Antisauvagine-30 TFA (220673-95-0 free base)
Catalog No. T10338
Alias aSvg-30 TFA, Antisauvagine-30 TFA
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
Antisauvagine-30 TFA (220673-95-0 free base)
Catalog No. T10338Alias aSvg-30 TFA, Antisauvagine-30 TFA
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $531 | Backorder | |
| 5 mg | $1,586 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively. |
| Targets&IC50 | CRFR2β (mouse):(kd)1.4 nM , CRFR1:150 nM (kd) |
| In vitro | Antisauvagine-30 prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. It did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice [1][2]. |
| In vivo | Antisauvagine-30 (i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2]. Antisauvagine-30 injected i.c.v. elicits a significant anxiogenic effect [3]. |
| Alias | aSvg-30 TFA, Antisauvagine-30 TFA |
| Molecular Weight | 3764.28 |
| Formula | C163H275N48F3O49S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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