Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties with an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM, effectively targeting resistant Mycobacterium tuberculosis H37Rv isolates and displaying significant intracellular antimycobacterial activity with low cytotoxicity [1].

Antitubercular agent-27 (compound 1) exhibits significant antimycobacterial activity against resistant isolates of M. tuberculosis H37Rv with IC50 values of 2.4, 100, 120, 1.3, and 3.1 μM, MICs of 3.2, 140, 160, 2.4, and 4.2 μM, and IC90 values of 3.0, 120, 142, 2.2, and 3.5 μM for FQ-R1, INH-R1, INH-R2, RIF-R1, and RIF-R2, respectively [1]. Additionally, it shows antibacterial activity with MIC values of 0.80 μM (low oxygen) and 0.45 μM (normal oxygen), IC50 values of 0.23 μM (low oxygen) and 0.27 μM (normal oxygen), and IC90 values of 0.43 μM (low oxygen) and 0.35 μM (normal oxygen) [1]. The compound also demonstrates intracellular activity with an IC50 of 1.45 μM and IC90 of 1.61 μM, and exhibits low cytotoxicity with an IC50 of >100 μM [1].