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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37Rv isolates, displaying significant intracellular antimycobacterial activity with low cytotoxicity [1]. |
In vitro | Antitubercular agent-27 (compound 1) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC 50 s of 2.4, 100, 120, 1.3, 3.1 μM, MICs of 3.2, 140, 160, 2.4, 4.2 μM, IC 90 s of 3.0, 120, 142, 2.2, 3.5 μM for FQ-R1, INH-R1, INH-R2, RIF-R1, RIF-R2, respectively [1]. Antitubercular agent-27 (0-200 μM) shows antibacterial activity with an MIC value of 0.80 μM, IC 50 value of 0.23 μM, and IC 90 value of 0.43 μM in low oxygen condition, and an MIC value of 0.45 μM, IC 50 value of 0.27 μM, and IC 90 value of 0.35 μM in normal oxygen condition [1]. Antitubercular agent-27 (0-200 μM) shows intracellular activity with an IC 50 value of 1.45 μM, and IC 90 value of 1.61 μM, and low cytotoxicity with an IC 50 value of >100 μM [1]. |
Molecular Weight | 346.14 |
Formula | C14H8BrN3O3 |
Cas No. | 2460651-09-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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