Apoptosisinducer 20 (12) induces cell apoptosis by causing G2/M cell cycle arrest and activating caspase-3/7 during the M-block phase. This compound is a novel indole sulfonamide with anti-proliferative effects against various cancer cells and shows promise for research into new antimitotic drugs.

Apoptosis Inducer 20 effectively inhibits the growth of various cancer cell lines. The melanoma cell line MelMet5 is the most sensitive, closely followed by HeLa cells. At a concentration of 100 nM and after 24 hours of treatment, Apoptosis Inducer 20 induces cell cycle arrest at the G2/M phase and triggers apoptosis through the activation of caspase 3/7.