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AZ5385 functions as an EGFR-tyrosine kinase inhibitor and also acts as a blocker of the HRV-2 virus, with an EC 50 value of 0.35 µM. It impacts the late stage of the viral life cycle [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | AZ5385 functions as an EGFR-tyrosine kinase inhibitor and also acts as a blocker of the HRV-2 virus, with an EC 50 value of 0.35 µM. It impacts the late stage of the viral life cycle [1]. |
In vitro | AZ5385 has a CC50 of 9 µM against HeLa cells over 72 hours [1]. When AZ5385 is pre-incubated for 3 hours before viral addition and then co-incubated with the virus at 37°C for 72 hours, it inhibits the infection of HEp-2 cells by HRV-16 and RSV A2 strains, with EC50 values of 3.6 µM and 0.4 µM, respectively [1]. |
Molecular Weight | 460.89 |
Formula | C22H22ClFN4O4 |
Cas No. | 848439-89-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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