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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $427 | 6-8 weeks | |
25 mg | $1,400 | 6-8 weeks | |
50 mg | $1,820 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow. |
In vitro | AZD2906 is a selective glucocorticoid receptor (GR), with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1]. |
In vivo | AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days[1]. AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats. And it exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats[1]. |
Molecular Weight | 460.5 |
Formula | C26H25FN4O3 |
Cas No. | 1034148-15-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (271.44 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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