Shopping Cart

Remove All

Your shopping cart is currently empty

Bapotulimab

Resource Download

Bapotulimab

Catalog No. T78304Cas No. 2359413-58-2

Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting the immunoglobulin-like domain-containing receptor 2 (ILDR2), and it exhibits antitumor and immunosuppressive effects [1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
1 mg	Inquiry	Backorder
5 mg	Inquiry	Backorder

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting the immunoglobulin-like domain-containing receptor 2 (ILDR2), and it exhibits antitumor and immunosuppressive effects [1].
In vitro	Bapotulimab inhibits the immunosuppressive effect of ILDR2 on T cell activation. This agent exhibits cross-reactivity between humans and mice, attributed to a 98% sequence identity in the extracellular domain between human and murine orthologs of ILDR2 [1]. Bapotulimab (BAY-1905254; at concentrations of 5, 25, 100, or 500 ng/mL) enhances T cell activation and promotes the proliferation of antigen-specific T cells in vitro [1].
In vivo	Bapotulimab (BAY-1905254; 10 mg/kg; intraperitoneal injection; administered on days 1 and 4) demonstrated a significant increase in antigen-specific T-cell proliferation and cytotoxicity [1].
Alias	BAY-1905254

Chemical Properties

Cas No.

2359413-58-2

Storage & Solubility Information

Storage

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BAY1905254BAY 1905254Bapotulimab