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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $656 | 8-10 weeks | |
25 mg | $1,310 | 8-10 weeks |
Description | BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 is the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo[1]. |
In vivo | BAY-298 administered orally at dosages ranging from 4.5 to 72 mg/kg/day over a period of 8 days, leads to a dose-dependent reduction in serum estradiol levels in proestrus in intact female rats. Additionally, when administered to female and male Wistar rats either intravenously (iv) at a dosage of 0.5 mg/kg or orally (po) at 2 mg/kg, BAY-298 exhibits half-lives of 31 hours and 33 hours, respectively, for iv and po routes. The maximum serum concentrations (Cmax) achieved are 0.28 kg/L for iv and 0.066 kg/L for po administration. |
Molecular Weight | 473.93 |
Formula | C27H21ClFN3O2 |
Cas No. | 2471978-97-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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