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Bexlosteride (LY300502), a benzoquinolinone derivative, functions as a human type I 5α-reductase inhibitor. It demonstrates metabolic inhibition, antiproliferative, and antisecretory activities specifically in LNCaP human prostatic adenocarcinoma cell cultures, positioning it as a potent agent for prostate cancer research [1] [2].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 2.033 € | 6-8 weeks | |
50 mg | 2.645 € | 6-8 weeks | |
100 mg | 3.344 € | 6-8 weeks |
Description | Bexlosteride (LY300502), a benzoquinolinone derivative, functions as a human type I 5α-reductase inhibitor. It demonstrates metabolic inhibition, antiproliferative, and antisecretory activities specifically in LNCaP human prostatic adenocarcinoma cell cultures, positioning it as a potent agent for prostate cancer research [1] [2]. |
In vitro | Bexlosteride effectively inhibits the reductive metabolism of [3 H-T] in LNCaP cells in a concentration-dependent manner, displaying an IC 50 of 5.77 nM[1]. At concentrations above 10 nM, it significantly counteracts the Testosterone-induced promotion of LNCaP cellular proliferation and completely inhibits Testosterone's mitogenic effects on these cells at 1000 nM[1]. Furthermore, Bexlosteride markedly opposes Testosterone-induced PSA secretion at concentrations of 30 nM or higher[1]. |
Molecular Weight | 249.74 |
Formula | C14H16ClNO |
Cas No. | 148905-78-6 |
Relative Density. | 1.202 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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