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Bis-NH2-PEG2

Name: Bis-NH2-PEG2
Brand: TargetMol
SKU: T16663
Price: 195 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16663Cas No. 929-59-9

Alias PROTAC Linker 19

Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.

Bis-NH2-PEG2

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Catalog No. T16663Alias PROTAC Linker 19Cas No. 929-59-9

Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.
In vitro	PROTACs consist of two ligands linked together; one targets the E3 ubiquitin ligase and the other targets the desired protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Alias	PROTAC Linker 19

Chemical Properties

Molecular Weight	148.2
Formula	C₆H₁₆N₂O₂
Cas No.	929-59-9
Relative Density.	1.015 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (1686.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.7476 mL	33.7382 mL	67.4764 mL	337.3819 mL
5 mM	1.3495 mL	6.7476 mL	13.4953 mL	67.4764 mL
10 mM	0.6748 mL	3.3738 mL	6.7476 mL	33.7382 mL
20 mM	0.3374 mL	1.6869 mL	3.3738 mL	16.8691 mL
50 mM	0.1350 mL	0.6748 mL	1.3495 mL	6.7476 mL
100 mM	0.0675 mL	0.3374 mL	0.6748 mL	3.3738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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