Bis-propargyl-PEG6 is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during the synthesis of PROTACs. Its application includes the generation of polymer-linked multimers of guanosine-3', 5'-cyclic monophosphates[1].

Bis-propargyl-PEG6 facilitates the synthesis of polymer-linked guanosine-3', 5'-cyclic monophosphate multimers, serving as vital reagents in signal transduction research. These multimers enable modulation of cyclic nucleotide-regulated binding proteins and their isoenzymes, and function as ligands in affinity chromatography. Additionally, they are useful in generating antibodies and for various diagnostic applications, such as on chip surfaces[1].