Powder: -20°C for 3 years | In solvent: -80°C for 1 year
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 4-5 weeks | $ 75.00 | |
5 mg | 4-5 weeks | $ 283.00 | |
10 mg | 4-5 weeks | $ 423.00 | |
50 mg | 4-5 weeks | $ 1,390.00 |
Description | The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro. |
Molecular Weight | 618.04 |
Formula | C28H43Cl3N6O3 |
CAS No. | 1808255-64-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL
DMSO: 5 mg/mL
You can also refer to dose conversion for different animals. More
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BIX01294 (hydrochloride hydrate) 1808255-64-2 hydrochloride Hydrate BIX01294 BIX 01294 BIX-01294 (hydrochloride hydrate) BIX-01294 inhibitor inhibit