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BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2].
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50 mg | Inquiry | Inquiry |
Description | BMV109 is a quenched probe designed to emit fluorescence upon being cleaved and covalently bound by active cathepsin proteases. This property of BMV109 is utilized in tumor imaging [1] [2]. |
In vitro | BMV109 (compound 8; 0.05 µM, 0.1 µM, 0.5 µM, 1 µM, 5 µM) labels all target cysteine cathepsins (B, S, L, X) with equal intensity in live RAW cells [1]. |
In vivo | In a mouse model of breast cancer, BMV109 (Compound 8; 20 nmol; intravenous injection) achieved tumor-specific fluorescence signals [1]. Animal Model: Balb/c mice bearing 4T1 cells [1]. Dosage: 20 nmol. Administration: Tail vein. Result: High-intensity, tumor-specific fluorescence activation was observed. |
Alias | BMV-109, BMV109, BMV 109 |
Molecular Weight | 2138.37 |
Formula | C107H108F4N10O23S5 |
Cas No. | 1458731-58-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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