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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,140 | 6-8 weeks | |
50 mg | $2,785 | 6-8 weeks | |
100 mg | $3,520 | 6-8 weeks |
Description | BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells. Additionally, it effectively down-regulates the c-Myc level in 22RV1 cells. Due to its properties, BRD4 Inhibitor-15 is a valuable compound for research related to prostate cancer [1]. |
In vitro | BRD4 Inhibitor-15 (also known as compound 13) demonstrates significant anti-proliferative effects on both enzalutamide-resistant 22RV1 cells and LNCap cells. Specifically, it exhibits half-maximal inhibitory concentration (IC50) values of 8.27 ± 0.28 μM and 7.33 ± 0.49 μM for each cell line, respectively [1]. |
Molecular Weight | 359.42 |
Formula | C22H21N3O2 |
Cas No. | 2761366-60-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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